Presse Med
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DISEASE ONSET: In adolescents, the different aspects of mood disorders and psychoses are closely related. The first episode of what will become schizophrenia is often suggestive of a mood disorder. The inverse is also true. Frequently, a psychotic state is the inaugural manifestation of a mood disorder.
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FIRST INTENTION PREVENTION: Lithium is the first intention preventive treatment for bipolar disorders. It the most effective choice in this indication and provides the most benefit for the patient, particularly the young patient still in the process of maturation.
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Review Comparative Study
[Prevention of venous thromboembolism in polytraumatized patients. Epidemiology and importance].
Unfractionated heparin, low-molecular-weight heparin (LMWH), mechanical compression, and vena cava filters are part of a large panel of chemical or physical methods proposed to trauma patients as prophylaxis against venous thromboembolism. This prophylactic strategy is based on a 1961 autopsy survey showing a 16.6% rate of pulmonary embolism in this population. The objective of this study was to assess the incidence of deep venous thrombosis (DVT) and pulmonary embolism (PE) in multiple trauma patients. ⋯ Current methodological imperfections make it impossible to correctly assess the incidence of DVT and PE in the multiple trauma population. Studies with a rigorous methodology using a precise stratification of the trauma injuries are required to determine the real risk for DVT/PE in trauma patients and to assess the impact of early systematic prophylaxis.
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Comparative Study
[Drug information and prescription guidance: role of regional centers of pharmacovigilance].
MISSIONS: Drug information is one of the missions of the French Regional Pharmaco-Vigilance Centers together with the evaluation of adverse drug reaction (ADR) reports, expertise, teaching and research. SERVICES: Physicians and other health professionals call their regional center (the address and phone numbers are on the first pages of the Vidal, the French national drug compendium) for any kind of information pertaining to adverse drug reactions or proper use of drugs such as drug use in pregnancy or lactation.
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ESTABLISHMENT: The European pharmacovigilance system has been operating since 1995 when the European Agency for the Evaluation of Medicinal Products as well as two new European registration procedures were established.