Presse Med
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THE MAIN OBJECTIVES OF THE CRITICAL REVIEW OF THE PUBLICATION OF A CLINICAL TRIAL: Are to underline the biases that may influence the validity and credibility of the results and to assess the quantity of the effect observed and the potential clinical impact.
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Case Reports
[Pulmonary strongyloidiasis complicated by E. coli meningitis in a HIV-1 and HTLV-1 positive patient].
Disseminated strongyloidiasis occurs in immunodepressed patients, notably those infected by retroviruses. ⋯ In HIV-infected patients exhibiting severe strongyloidiasis, research for an HTLV co-infection is recommended.
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THE EFFICACY OF LEVOFLOXACIN: In treating community-acquired pneumonia (CAP) has been assessed during 5 large clinical trials (including 4 controlled randomized trials). 1067 PATIENTS HAVE BEEN TREATED BY LEVOFLOXACIN: And 645 by a comparator. Success rates were identical between levofloxacin and comparator ranging from 70.6% to 84.2% for levofloxacin treated patients, and from 75% to 85.7% for comparators treated patients. 549 PRESUMED OR PROVED PNEUMOCOCCAL PNEUMONIA: Have been treated by levofloxacin with a success rate ranging from 83% to 100%, and 379 have been treated by a comparator with a success rate ranging from 90% to 95%. ⋯ The severity of the patients ranged between studies from moderate to severe. PROOFS COMING FROM THOSE CLINICAL TRIALS: Show the efficiency of levofloxacin in the treatment of moderate to severe community acquired pneumonia in adults, and in the treatment of presumed or proved pneumonia, with or without bacteraemia.
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CRANIO-ENCEPHALIC TRAUMAS: Scanography remains the examination of choice. However, MRI can be useful in diagnosis of diffuse axional lesions, not clearly visualized with scanography, and for screening the subsequent lesions. ⋯ If multiple sclerosis is suspected, MRI is considered as the principle para-clinical examination able to confirm the diagnosis with the first episode. It also supplies data for the diagnosis of metabolic, toxic and degenerative diseases.
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Many asthmatics have few or no symptoms despite severe obstruction of the airways. Physicians confronted with this phenomenon may therefore underrate the severity of the asthma and treatment may be insufficient. We studied the capacity of a group of general practitioners to assess the bronchial obstruction of patients presenting with varying degrees of symptoms and obstruction. ⋯ General practitioners may underrate the severity of asthma, despite substantial obstruction of the respiratory tract, if there are few symptoms and hence under-treat falsely normal patients.