Presse Med
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Randomized Controlled Trial Clinical Trial
[Proof of the pharmacodynamic activity of Flector Plaster in healthy volunteers and patients suffering from osteo-arthritis of the knee].
STUDY OF HEALTHY VOLUNTEERS: This double blind study (bioadhesive plaster of diclofenac epolamine versus placebo), showed that the application of diclofenac epolamine for 24 hours induced a selective hypoanalgesic effect on the muscle, proportional to the degree of hypersensitivity to the pain observed in baseline conditions. The enhanced effect on the hyperalgic muscle can be explained by the direct impact of the active ingredient on the nociceptors and/or its inhibiting effect on the local production of prostaglandins. STUDY OF PATIENTS SUFFERING FROM BILATERAL OSTEO-ARTHRITIS OF THE KNEE: In a 24 hour trial of the treatment (bioadhesive plaster impregnated with diclofenac epolamine (Flector Plaster) versus placebo), the active treatment had a significant impact on the spontaneous pain during rest that was enhanced during mouvement. In a longer term trial (72 hours), the regression of the spontaneous pain on the visual analog scale appeared even more significant, still lasting 96 hours after withdrawal of the plaster, not only at rest but also on mouvement.
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THE SITUATION: Islet transplantation stands as a promising curative treatment for type 1 diabetes. Improvements of this still experimental procedure were recently obtained through the modification of the immunosuppressive regimen and the increase of the islet mass delivered to the patient. Several centers have now reported rates of insulin-independence of 80% and beyond after one year, although these cohorts of patients are limited, and the results restricted to experienced centers.
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French doctors' smoking habits may interfere with the effectiveness of smoking prevention measures and particularly when providing minimal advice. ⋯ The incidence of smoking among doctors in the Department of Vienne remains too high and minimal intervention on smoking cessation is still insufficient. However, doctors who had never smoked provided minimal advice more often than those who currently smoked or had quit.