Presse Med
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Non-invasive ventilation can make it possible to avoid endotracheal intubation in patients with acute respiratory failure. Its use in mobile intensive care unit requires assessment of its feasibility. ⋯ Despite the limits of our study we were able to demonstrate the feasibility of non-invasive ventilation in prehospital setting. Future studies should be conducted on larger cohorts in order to specify the interest of non-invasive ventilation in such conditions.
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Comparative Study
[Comparison of the pharmacologic effect of diacerein and a selective COX-2 inhibitor in the mouse induced-granuloma model].
ANIMAL MODEL OF DEGENERATIVE JOIN DISEASE: A mouse model of joint disease with an induced granuloma has demonstrated that diacerein inhibits loss of hydroxyproline and proteoglycans in joint cartilage, an effect not observed with conventional nonsteroidal antiinflammatory drugs (NSAID) or with a specific inhibitor of cyclooxygenase-2 (COX-2). Specific COX-2 inhibitors could thus be beneficially combined with disease modifying osteoarthritis drugs DMOD such as diacerein. ANTIINFLAMMATORY EFFECTS OF COX-2: During the process of inflammation, COX-2 activity appears to occur at two specific time points, with a peak at 2 hours, associated with maximal activity of PGE(2) synthase (proinflammatory prostaglandin) and a second peak after 48 hours, associated with increased levels of PGD(2) and cyclopentenones (anti-inflammatory prostaglandins). ⋯ Treatment with NSAID or selective anti-COX-2 agents appears to have a beneficial effect during acute phases of inflammation but their use in long-term regimens appears to have less favorable effects. Use of long-action symptomatic treatments without any apparent effect on COX-2, for example diacerein, could protect against the potentially deleterious effects of COX-2 inhibition.
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Review Comparative Study
[Comparative efficacy of antalgesics and non-steroidal anti-inflammatory drugs].
EFFICACY OF ANALGESICS AND NON-STEROIDAL ANTI-INFLAMMATORY DRUGS: A systematic review of randomized clinical trials demonstrates that common analgesics and nonsteroidal anti-inflammatory drugs (NSAID) provide short-term pain relief for rheumatism-related pain. There have however been few controlled randomized studies on the efficacy of analgesics against rheumatism-related pain. ⋯ Finally, trials comparing NSAID with analgesics are scarce and heterogeneous. The comparative efficacy of these two types of compounds remains difficult to interpret.
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SYMPTOMATIC EFFECTS OF DIACEREIN: Data obtained from several clinical trials have demonstrated that relief of joint pain obtained with the interleukin-1 inhibitor diacerein is comparable with that observed with non-steroidal anti-inflammatory drugs (NSAIDS) after four to six weeks of treatment and that relief persists after treatment withdrawal. Patients taking diacerein are less handicapped, use less NSAID and/or analgesics, and have lower demands for care as well as an improved quality of life. RADIOGRAPHIC The ECHODIAH study conducted to evaluate the structure-modifying effect of diacerein in hip osteoarthritis.
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Comparative Study Clinical Trial
[Clinical and radiographic status of patients in the ECHODIAH study who underwent THA Pertinence of the pain-function index for operative decision making].
The ECHODIAH study conducted to evaluate the chondromodulator effect of diacerein on the osteoarthritic hip joint has provided epidemiological data on patient symptoms at three-month intervals. Patients with degenerative hip joints evaluated their pain and handicap on visual analog scales. The Lequesne functional score was also determined. A radiographic study was performed every year. ⋯ Among the 507 patients included in the study, 135 underwent total hip arthroplasty. Clinical and radiological evaluations of the operated patients demonstrated that the Lequesne functional score was the best predictive factor with an optimal cutoff at 12 points. The second best predictive factor was the radiographic measurement of the joint space.