Presse Med
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FUNCTIONS OF THE ENDOTHELIUM: The endothelium plays a pivotal role in regulating vasomotor tone, vessel permeability, blood cell extravasation, and antiatherogenic, antithrombogenic and antiadhesive processes.
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MDR GENES: Overexpression of MDR genes leads to the production of glycoprotein P (PGP) that can use protease inhibitors as a substrate. This overexpression of MDR genes appears to be the cause, at least partially, of resistance to protease inhibitors by induction of very low intracellular inhibitor concentrations.
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A DISEASE ON THE COME BACK: West Nile encephalitis has been known since the thirties. It generally occurs in Africa and Western Asia, rarely in Europe. The disease has disappeared from France since 1960, but has reappeared in the United States and in Israel. ⋯ After 2 to 15 days incubation, the patient experiences fever, headache, diffuse pain, and sometimes skin rash. Disorientation, stiff neck, convulsions and paralysis then develop and lead to death in 10 to 15% of the cases. No antiviral agent is active against the West Nile virus.
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Case Reports
[Digital necrosis in a patient with anorexia nervosa. Association of vasculopathy and radial artery injury].
Patients with anorexia nervosa can develop distal vasculopathy sometimes leading to severe Raynaud's phenomenon or acrocyanosis. We report a cas of anorexia nervosa-related vasculopathy associated with iatrogenic injury to the radial artery that led to digital necrosis. ⋯ We report a case of digital necrosis occurring after arterial puncture for blood gas analysis in a patient with a vascular bed weakened by tobacco and cannabis intoxication but also by anorexia nervosa-related vasculopathy. This observation underlines the potentially dangerous nature of invasive intravascular procedures in this context. Indications for vessel puncture must be assessed with prudence.