Presse Med
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Randomized Controlled Trial Clinical Trial
[35th Congress of the American Society of Clinical Oncology. Results of an extensive randomized test series].
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Randomized Controlled Trial Comparative Study Clinical Trial
[Pristinamycin in the treatment of acute communicable pneumopathies in adults].
ALTERNATIVE TO BETA-LACTAMS: Due to the rapid and increasing development of resistance in the two main bacteria, S. pneumoniae and H. influenzae, it is important to determine whether pristinamycin, with known efficacy against these germs, could be a useful alternative to beta-lactams for the treatment of adult acute community-acquired pneumonia.
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Randomized Controlled Trial Clinical Trial
[Pristinamycin in the outpatient treatment of acute sinusitis in adults].
TWO MAIN GERMS: The risk of severe complications of acute bacterial sinusitis warrants empirical antibiotic therapy targeted against the two main causal agents: S. pneumoniae and H. influenzae.
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A MULTIFACTORIAL ORIGIN: Psoriasis is an inflammatory dermatosis resulting from abnormal epidermal homeostatis and characterized by hyperproliferation and abnormal keratinocyte differentiation as well as activation of the skinis immune system. This dermatosis is a prototype of multifactorial conditions implicating hereditary and environmental pathogenic mechanisms. TWO TYPES OF PSORISASIS: Familial psoriasis is observed early in life and is strongly associated with the major histocompatibility complex, particularly CW6, DR7, B1, and B57 molecules. The sporadic non-familial form develops later in life.
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THE CONTEXT: Psoriasic arthritis lies somewhere between rhumatoid polyarthritis and spondyloathropathy. Its prevalence is about 0.1% with a 1/1 sex ratio. Mean age at onset of symptoms is 40 years. ⋯ DISEASE SEVERITY: In general psoriasic arthritis is a benign condition. Severe forms have however been described with erosion and osteolysis involving the distal interphalangeal joints. Typical radiological may be observed.