Presse Med
-
Randomized Controlled Trial Clinical Trial
[Laryngeal edema after extubation. Do corticosteroids play a role in its prevention?].
The role of corticosteroids in the prevention of post-extubation laryngeal oedema was evaluated in a randomized study of 276 patients under mechanical ventilation. Fifty per cent of the patients received methylprednisolone 40 mg intramuscularly and intravenously. ⋯ Thus, the incidence of laryngeal oedema was not modified by corticosteroids. Regular prescription of corticosteroids does not seem to be useful before extubation of patients intubated with large volume, low-pressure balloon tubes.
-
Randomized Controlled Trial Clinical Trial Controlled Clinical Trial
[Treatment of acute alcoholic hepatitis with prednisolone. 45 patients].
Whether or not prednisolone (or prednisone) should be used to treat alcoholic hepatitis remains controversial. This new controlled study performed on 45 patients with steatosis, fibrosis or cirrhosis of the liver suggests that prednisolone is not effective: after a 3-month follow-up clinical course, biochemical alterations, anatomical lesions and portal hypertension were the same in patients treated with prednisolone and in those who did not receive that drug.