Rev Invest Clin
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Randomized Controlled Trial Comparative Study
[Decrease of folic acid and cognitive alterations in patients with epilepsy treated with phenytoin or carbamazepine, pilot study].
Phenytoin and carbamazepine were the antiepileptic drugs most frequently used in Mexico and throughout the world. Epileptic patients who take these drugs have a variety of collateral effects including the decrease of folates plasmatic level. Low seric folic acid concentration has been associated with a decline in cognitive functions. The administration of a combined treatment with folic acid could ameliorate these difficulties. ⋯ Treatment with folic acid is safe and without side effects, it improved the cognitive function in patients with epilepsy treated with phenytoin and carbamazepine.
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Historical Article
[Tobacco and tobacco use disorder in the history of Mexico and Europe].
The tobacco used for a long time by American and Caribbean natives was introduced into Europe at the end of XV century, and essentially during the XVI century, by travelers returning to their Fatherlands. After the tobacco industry was organized, several concerns arose regarding medical and social care for the workers in the tobacco factories. Medical and hygienic aspects were reflected in a whole chapter (the XVII) of the Ramazzini's Treatise on Medicine of Work, published in 1700. ⋯ In opposition to the predictions of some natives and visitors during the last centuries, with the passage of time, the tobacco habit instead of decreasing, became progressively more accentuated in all social classes. To aggravate conditions, at present, the noxious effects of the tobacco smoke are combined with those of environmental contamination. Recent epidemiological reports on the number and health conditions of smokers, as well as the National Antitobacco Program in Mexico, are mentioned.