Rev Invest Clin
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Comparative Study
[Elevation of total urinary catecholamines in patients with subarachnoid hemorrhage].
We designed a prospective study in order to evaluate total urinary catecholamines in patients with subarachnoid hemorrhage (SAH) and correlate them with some prognostic factors and its complications. We studied 24 patients: 19 were normotensive, five had had a previous arterial hypertension that persisted during the SAH, and five developed the hypertension during the SAH. The latter showed cardiac complications with a more severely affected Hunt and Hess scale and a higher level of excretion of urinary catecholamines than the normotensive patients (p < 0.003). The cases with previous arterial hypertension that persisted during the SAH had more complications than the normotensive patients but in a lesser degree compared to chose who developed the hypertension during the SAH.
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Traditionally, the renin angiotensin system (RAS) has been thought of primarily as an endocrine system that delivers circulating angiotensin II to target tissues. This peptide is a potent vasoconstrictor and a primary stimulus for aldosterone secretion. In addition, angiotensin II has many other targets such as kidney, heart and brain, from which it elicits different specific responses. ⋯ It has been proposed that the main function of the circulating RAS is to provide short-term cardiorenal homeostasis. The tonic control (e.g., adrenal and kidney) is influenced by the intrinsic tissue RAS. This new concept provides a broader outlook on the RAS and challenges its traditional endocrine role.
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We analysed DNA through Southern blot and polymerase chain reaction using blood samples of northeastern Mexican families affected by hemophilia A. Our aim was to identify possible carriers of the mutated gene by indirect detection using the Bcl I polymorphism (RFLP) at intron 18 of the factor VIII gene. The sample studied consisted of 43 individuals within eight families with hereditary hemophilia A. ⋯ The frequencies found for the Bcl I polymorphism were 63% for the 1.2 kb allelic fragment and 37% for the 0.9 kb allelic fragment. Heterozygote women were found in 48.2% of the families studied. Our results show that probably, the Bcl I RFLP is more useful for HA carrier diagnosis in our sample (northeastern Mexico).