Rev Invest Clin
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To estimate the cefuroxime pharmacokinetic parameters in critically ill pediatric septic patients using a Bayesian pharmacokinetic method and three serum drug assays per patient. ⋯ We offer a tentative cefuroxime pharmacokinetic model for critically ill pediatric septic patients which may be useful for the control of cefuroxime serum concentrations. Also, our study underscored the potential usefulness of a Bayesian pharmacokinetic approach as a tool for therapeutic drug monitoring in critically ill patients.
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Randomized Controlled Trial Multicenter Study Comparative Study Clinical Trial
[Postoperative analgesia using epidural administration of bupivacaine plus lidocaine].
To compare the postoperative analgesia of bupivacaine + lidocaine versus lidocaine in lower abdominal surgery. ⋯ The mixture of bupivacaine + lidocaine proved be an effective alternative for epidural use in lower abdominal surgery.
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To determine the effect that the change from French to English had on the impact of the Annales de l' Institut Pasteur. THEORETICAL REFERENCE: The Pasteur Institute journals have a prestige of over 100 years of existence and eight Nobel Prize winners in Physiology and Medicine. Changes through time on the impact of these journals can be monitored as they are included in databases of the ISI (Institute for Scientific Information). ⋯ The change of language did not increase the impact factor of the French journals.
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Comparative Study
[Interferon in the eradication of the Philadelphia chromosome in chronic myeloid leukemia].
To evaluate if human recombinant interferon alpha (IFN) combined with chemotherapy is able to suppress the Philadelphia chromosome clone in patients with chronic myeloid leukemia (CML). ⋯ Our results showed that: a) IFN in combination with chemotherapy induced partial or complete response in 30% of our cases; and b) intensive chemotherapy combined with IFN was not superior in terms of a cytogenetic response to treatment with monodrugs (BUS/HIDX) and IFN.