Saudi Med J
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Observational Study
Determining optimal cuff volume for cuffed endotracheal tubes commonly used in pediatric patients: A prospective observational study.
To determine an optimal cuff inflation volume to achieve safe cuff pressure (20-25 cmH2O) in cuffed endotracheal tubes (ETTs) with an inner diameter of 4.5, 5.0, and 5.5 mm, which are commonly used in pediatric anaesthesia clinical practice and to create a formula to determine the optimal cuff volume. ⋯ In this study, we suggested the optimal cuff volume to inflate the cuffs of ETTs 4.5, 5.0, and 5.5, which are frequently used in pediatric anaesthesia practice, in the appropriate cuff pressure range.ClinicalTrials.gov ref. no.: NCT04948359.
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To evaluate belinostat's (PXD101) activity on MCF-7 breast cancer stem cells (CSCs) via Wnt, Notch, and Hedgehog. ⋯ Belinostat has a potential effect on the differentiation and self-renewal of breast CSCs.
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To compare Ras-related associated with diabetes (RRAD) across different species and to identify specific biomarkers for cancer therapy. ⋯ This research offers insights into the potential of RRAD as a therapeutic target in various organisms and highlights the importance of biomarker identification in drug development.
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Multicenter Study
Epidemiology of Clostridioides difficile infection at a tertiary care facility in Saudi Arabia: Results of prospective surveillance.
To determine the incidence of Clostridioides difficile infection (CDI) and the frequency of known risk factors. ⋯ In our hospital, HO-CDI incidence rate is lower than that in high-income countries. National multicenter surveillance is needed to evaluate the actual burden of CDI in Saudi Arabia.
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Systemic cobalt-chromium (Co-Cr) toxicity following a total hip replacement is a rare complication that may sometimes lead to fatal consequences. We report a case of a 64-year-old woman, who presented with Co-Cr toxicity after revision of fractured ceramic components with metal-on-polyethylene. Systemic toxicity occurred a year after surgery and was expressed brutally with mostly central neurological symptoms. ⋯ Prosthetic revision with a metal bearing surface after a history of fracture of the ceramic bearing component should be avoided. Orthopedic surgeons and the different medical actors should be aware of this rare but serious complication to allow earlier management. Above all, multidisciplinary management is primordial to allow correct diagnosis and appropriate treatment.