Singap Med J
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We studied the efficacy of sequential intravenous-oral pefloxacin therapy in community-acquired lower respiratory tract infection in 24 patients with one or more underlying conditions. Twenty-eight patients were enrolled into the study but only 24 patients were evaluated. There were 16 males and 8 females with a mean age of 66.9 +/- 11.2 years (mean +/- SD, range 46 to 87 years). ⋯ Pefloxacin was well tolerated. There were few adverse effects and none of the patients required a change of antibiotic. Pefloxacin was an effective and well tolerated treatment for respiratory tract infection and had the advantage of broad in-vitro antibacterial activity, twice daily dosing and sequential availability in an intravenous and oral formulation.
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Glycosylated haemoglobin levels (HbA1) were determined in 489 normal pregnant Singaporean women, attending a diabetic screening programme using a 50g glucose challenge test. All subjects had no risk factors for diabetes mellitus nor a history of previous gestational diabetes. They were selected when the 1h 50g glucose challenge (GCT) is < 6.66 mmol/l or a 2h post-glucose level of < 7.77 mmol/l (a 75g OGTT is repeated within a week of an abnormal GCT). ⋯ The HbA1 appeared to be low at early gestation with nadir at 21-24 weeks and thereafter returned to initial levels at term. In Chinese, mean HbA1 levels, random plasma glucose and 1h glucose challenge were significantly higher than those of the Malays but not the Indians. In referring to these levels, the variation within gestation and ethnic group must also be considered.