Terapevt Arkh
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The rise of the sepsis incidence at therapeutic hospitals, the emergence of new forms and evolutionally new mechanisms of infection, insufficient efficacy of antibacterial therapy necessitate the search of novel approaches to the treatment of sepsis. The use of plasmapheresis (PP) in 27 sepsis patients allowed a two-fold reduction of the lethality as compared to that in the control group. The main mechanisms by which PP acts may involve deblockade of the system of phagocytosing mononuclears, enhancement of the efficacy of antibacterial therapy, protective action on the system of natural detoxication of the body.
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The paper is concerned with the results of studying the concentration of circulating immune complexes and immune system (the number of lymphocyte populations and subpopulations in the peripheral blood, the level of serum immunoglobulins) in 45 patients aged 10 to 72 years with hemorrhagic vasculitis depending on the disease pattern and course before and after the treatment. The patients suffering from hemorrhagic vasculitis manifested appreciable changes in humoral immunity and negligible derangement of cellular immunity associated with dramatic enhancement of complex formation. The intensity of the alterations was discovered to be dependent on the pattern and course of the disease.
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Comparative Study
[The mechanisms regulating pulse-wave spreading time in a biological feedback regimen in patients with borderline arterial hypertension and in healthy subjects].
The regulatory mechanisms of pulse transit time (PTT) during biofeedback training were studied by noninvasive cardiovascular monitoring in borderline hypertensive and normotensive subjects. Hemodynamic parameters were used as indirect indices of autonomous nervous system activity. All the patients were capable of increasing PTT. ⋯ In the initial 5 sessions, there was the most significant decrement of sympathetic, especially beta-adrenergic activity, expressed in the reduction of the myocardial contractility and cardiac output. In the retraining period (6 to 12 sessions), the leading role was played by the reduction of the arterial tone and total peripheral resistance. Respiratory arrhythmia rose in both cases as a result of the increased parasympathetic activity.