Terapevt Arkh
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Randomized Controlled Trial
[Visceral sensitivity in diagnostics and treatment of severe irritated bowel syndrome].
Irritable bowel syndrome (IBS) is a biopsychosocial model based on the malfunction of "brain-intestinal linking". ⋯ The insufficient effect of the trimebutine therapy can be explained by the somatoform disorders persistence in patients from group 1. Meanwhile SNRI-duloxetine therapy in group 2 showed a clinical remission of IBS: such as a reliable relief from pain and diarrheal syndrome, as well as an increase in the HF threshold. Thus, Duloxetine is a promising treatment for severe IBS with somatoform disorders. BDT can be used as an objective criterion to diagnose and evaluate the effectiveness of therapy in patients with IBS.
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The assessment of pancreatic resection volume influence on exo- and endocrine pancreatic functions. ⋯ The exo- and endocrine function of the pancreas is restored in more than 80% of patients after DR. Probably it could be associated with the activation of the pancreatic compensatory abilities.
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To increase detection frequency and reduce the risk of celiac disease complications based on a comprehensive analysis of patterns of iron deficiency states in the active period of celiac disease in children. ⋯ Iron deficiency states in the active period of celiac disease have been diagnosed in 73.3% of patients, with the highest incidence observed in infants and older children.