Terapevt Arkh
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The article is a set of recommendations for the interpretation of electrocardiography and echocardiography data in patients with suspected amyloidosis of the heart. Amyloid cardiomyopathy is a progressive disease characterized by a detailed picture of congestive heart failure, poor quality of life and poor prognosis. Currently, medications have appeared that can improve the prognosis in patients with amyloidosis of the heart. Therefore, raising awareness of specialists about specific instrumental signs of the disease is an important and urgent task.
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Multicenter Study Observational Study
[Irritable bowel syndrome in the Russian Federation: results of the ROMERUS multicenter observational study].
Irritable bowel syndrome (IBS) is one of the most common functional disorders of the gastrointestinal tract. According to Russian guidelines, a standard examination using laboratory and instrumental evaluation methods, including colonoscopy, should be performed to establish the diagnosis of IBS. ⋯ IBS patients in the Russian Federation were characterized. The diagnosis of IBS, established following the Rome IV criteria, is confirmed by the results of a standard examination in 96.3% of patients. The Rome IV criteria for the IBS diagnosis make it possible to establish a diagnosis with a probability of 94.7%. For 6 months of follow-up, there was a clinical improvement with a decrease in the severity of symptoms and a QoL improvement.
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Randomized Controlled Trial
[New opportunities for complex treatment of oropharyngeal candidiasis in HIV-infected patients in the later stages of the disease].
Treatment of recurrent oropharyngeal candidiasis (OPC) in HIV-infected patients is a serious clinical problem due to the emergence of resistant Candida strains, the risk of invasive disease, and high economic costs, which warrants the need for new treatment regimens. ⋯ This treatment regimen for oropharyngeal candidiasis in patients with HIV infection in the later stages of the disease (IVB-IVC) with fluconazole and Tonsilgon® N is effective, which is confirmed by a significantly more pronounced regression of clinical signs (pM-U<0.01), as well as an increase in the level of secretory immunoglobulin A in the oral fluid (from 0.62±0.33 g/L to 0.81±0.18 g/L; p<0.05).
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Historical Article
[Activity of N.A. Semashko during the evacuation of the 1st Moscow Order of Lenin Medical Institute to Ufa (1941-1942)].
An attempt is made to systematize the main directions of N. A. Semashko's activity during the evacuation of the 1st Moscow Order of Lenin Medical Institute (MOLMI) during the Great Patriotic War to Ufa (October 1941 - March 1942) is undertaken. ⋯ Semashko actively worked in several directions during complicated conditions of evacuation. Besides pedagogical and scientific activities, he was occupied with the training of scientific-pedagogical personnel, took part in advanced training of physicians and medical workers, organized educational work with the population, delivered brilliant lectures to the crowded halls. In addition, as the first People's Commissar of Health of the RSFSR, he helped the People's Commissariat of Health of the Bashkir ASSR in organizing the work of evacuation hospitals and rendering assistance to health care institutions located on the territory of the Bashkir ASSR.
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Primary immunodeficiencies (PIDs), now known as inborn errors of immunity, are a group of inherited diseases caused by defects in the genes that control the immune response. Patients with PIDs have risks of developing a severe course and/or death in COVID-19. Passive immunization with long-acting monoclonal antibodies (MABs) to SARS-CoV-2 should be considered as pre-exposure prophylaxis in patients with PIDs. Tixagevimab/cilgavimab is a combination of MABs that bind to the SARS-CoV-2 spike protein. ⋯ The use of tixagevimab/cilgavimab in patients with PIDs is effective as pre-exposure prophylaxis and reduces the risk of severe COVID-19.