Terapevt Arkh
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Comparative Study
[Immunosuppressive therapy with the use of cyclosporin A in the late period after a kidney transplant].
A study was made of the results of kidney transplantation in 90 patients who received three-component immunosuppressive therapy (cyclosporin, azathioprine and prednisolone) in the induction phase, followed by cyclosporin conversion in the phase of maintenance therapy. The second patients' group (39 cases) received permanent three-component immunosuppressive therapy. Analysis of the data obtained makes it possible to regard the use of cyclosporin advisable not only in the induction, but also in the maintenance phases of immunosuppressive therapy.
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Gallbladder function and lipid composition of bile were examined for the first time in the indigenous population of the extreme north of the USSR. Bile from Evens and Evenki was not found to be oversaturated with cholesterol, with motor function of the gallbladder being characterized by hypermotility. This is of interest, since there are data on the protein-lipid nature of nutrition in aborigines of the North.
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Comparative Study
[The neuroendocrine reactions in patients with chronic bronchitis in a region of the northeastern USSR].
The author describes differences in the manifestations of mutually determined reactions of the sympathoadrenal and hypophyseoadrenocortical systems in their interaction with the biologically active substance serotonin in healthy persons (124) and patients suffering from chronic bronchitis at different times of living on the Chukot Peninsula. The most perfect system of the protective effect on the part of the neuroendocrine complex can be seen in chronic bronchitis patients within the first 3-5 years of living in the North as compared with the reaction of the neuroendocrine system in the examined patients with a longer "northern record" (10-15 years and more).
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A study was made of the causes and factors that determine disability in 102 able-bodied patients suffering from essential hypertension (a random sample), who were acknowledged invalids for the first time in 1989. Analysis of the shortcomings in the organization of the treatment and prophylactic aid to the population made it possible to outline the main trends in disability prevention in patients suffering from essential hypertension.