Terapevt Arkh
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Clinico-genetic analysis was performed in 530 patients with chronic bronchitis (CB) and in 760 healthy persons. The frequency of aggravated heredity in the patients' parents was significantly higher than that in the healthy persons' parents (21.3 +/- 1.8 and 12.1 +/- 1.2%, respectively, P less than 0.05), this predominance being associated with such diseases as chronic bronchitis and bronchial asthma. A study of a type of familial aggravation has shown that the probability of CB development in descendants increases substantially if mother suffers from CB, CB morbidity among girls being significantly higher than that among boys. ⋯ A study of the blood antigens ABO, Rh, MN, P, Hp has revealed different sensitivity of persons with different genetic blood markers to CB. Differences in the frequency of antigen combinations were also revealed in the patients and in the healthy persons. The results obtained indicate the appropriateness of further development of genetic investigations in pulmonology.
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Cryoglobulins were studied in the sera of 40 unselected pSS patients. The nature of the cryoglobulins was defined using a very fast and sensitive resolution electrophoresis technique combined with immunofixation. Thirty-five per cent of SS patients were shown to have circulating IgMk mixed monoclonal cryoglobulins. ⋯ Patients with cryoglobulins had lower serum C4 levels compared to patients without cryoglobulins. These findings suggest that SS in addition to polyclonal B-cell hyperreactivity expresses a monoclonal process preceding the development of lymphoid neoplasia. Extraglandular manifestations of the syndrome may be associated with an immune complex mediated pathology.
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Acetylation phenotype distribution (activity of N-acetyltransferase enzyme) was studied in 29 patients with periodical disease (PD), 73 healthy persons (Armenians), and 20 patients (also Armenians) suffering from epithelial coccygeal cysts. The results obtained indicated the prevalence of slow acetylation phenotype (67%) in the entire Armenian population. ⋯ The other hereditary pathology, also specific for Armenians (epithelial coccygeal cysts), was characterized by another type of acetylation--a rapid one. The role of slow acetylation as a genetic marker of PD was discussed.
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HLA-antigens were studied in 116 Greek patients: 22 with pSS, 14 with sSS and RA, 26 with classical RA and 420 healthy controls. A statistically significant increase in HLA-DR5 was observed mainly in pSS patients with anti-Ro (SSA). A significant increase in HLA-B8, HLA-DR3 and HLA-DR5 was observed in pSS patients with anti-La (SSB) antibodies as compared to the controls.