Turk J Med Sci
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Prostate cancer is the most commonly diagnosed malignancy and the second most common cause of cancer deaths in the Western male population. Matrix metalloproteinases (MMPs) and tissue inhibitors of MMPs (TIMPs) modulate the remodeling of the extracellular matrix (ECM). The imbalance between MMPs and TIMPs may lead to an emergence of pathological processes such as cancer. In this study, the association between TIMP-2 (-418 G/C) and MMP-2 (-1306 C/T) polymorphisms and prostate cancer in the Turkish population was investigated. ⋯ Our results show that the TIMP-2 -418 (GC) genotype had a putative protective effect against prostate cancer.
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To investigate the value of measuring liver enzymes, red cell distribution width (RDW), and mean platelet volume (MPV) in predicting the development of gestational diabetes mellitus (GDM). ⋯ Our study results suggest that ALT, GGT, PCT, and PDW may be useful as predictors of impending GDM.
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To evaluate the relation between biochemical recurrence (BCR) of prostate cancer and the extent of positive surgical margins (PSMs), Gleason score (GS) of the tumor at the margins, and preoperative prostate-specific antigen (PSA) levels. ⋯ High preoperative PSA levels, PSMs, and tumors with high GS at the margins have a poor prognostic impact, and they correlate with a higher rate of BCR. Close follow-up of patients with PSMs with high GS and high levels of preoperative PSA is recommended.
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To investigate the causes and clinical characteristics of uveitis in patients presenting to a specialized eye hospital in Turkey. ⋯ Uveitis tends to affect patients between 20 and 40 years old. BD is the most common cause, leading to male predominance and a higher frequency of a chronic course.
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To measure the torsion angle of the humerus using images obtained via magnetic resonance imaging (MRI) in healthy volunteers and to evaluate outcomes with respect to sex and age groups. ⋯ Considering intersocietal anatomic differences, our study may shed light on torsion angle for Turkey by determining mean torsion angle value. Moreover, this study indicated that HTA can be successfully measured using MRI. We think that our outcomes can be used as a reference for prosthesis design and shoulder joint prosthesis replacement. Moreover, we also think that this study will provide benefits in examining pathologies related to the shoulder joint, such as recurrent anterior dislocation syndrome.