Neurology
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In treating PD, deep brain stimulation (DBS) has shown great promise in a series of uncontrolled studies. ⋯ The results suggest that DBS may be cost effective in treating PD if QOL improves 18% or more compared with those receiving best medical management. This underscores the need for randomized, controlled, prospective DBS experiments including QOL and economic components.
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Bilateral hippocampal damage is a risk factor for memory decline after anterior temporal lobectomy (ATL). ⋯ Bilateral hippocampal atrophy in the presence of left TLE is associated with worse verbal memory before and after ATL compared with patients with unilateral hippocampal volume loss or right TLE with bilateral hippocampal volume loss.
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Randomized Controlled Trial Clinical Trial
Lamotrigine reduces painful diabetic neuropathy: a randomized, controlled study.
To study the efficacy of lamotrigine in relieving the pain associated with diabetic neuropathy. ⋯ Lamotrigine is effective and safe in relieving the pain associated with diabetic neuropathy.
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Five cases of presumed nicotine withdrawal delirium among brain-injured patients treated in a neurologic intensive care unit are presented. Each patient had a history of heavy tobacco use and experienced dramatic and sustained clinical improvement within hours of transdermal nicotine replacement. These preliminary observations suggest that nicotine withdrawal may be an under-recognized cause of delirium in patients with acute brain injury.
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To study whether trains of subthreshold 1 Hz repetitive transcranial magnetic stimulation (rTMS) over premotor, prefrontal, or parietal cortex can produce changes in excitability of motor cortex that outlast the application of the train. ⋯ Subthreshold 1 Hz rTMS of the left premotor cortex induces a short-lasting inhibition of corticospinal excitability in the hand area of the ipsilateral motor cortex. This may provide a model for studying the functional interaction between premotor and motor cortex in healthy subjects and patients with movement disorders.