Neurology
-
To investigate the molecular genetic basis of cluster headache (CH), using a genome-wide scan and candidate gene strategy. ⋯ Cluster headache is a complex genetic disorder, with possible phenotypic and genetic heterogeneity compounding attempts at gene identification.
-
To describe the emerging profile of headache frequency following a 2-month drug-free period in patients with medication overuse. ⋯ These data demonstrate the benefit of withdrawal in already established medication overuse and support the existence of medication-overuse headache as a clinical entity.
-
Controlled Clinical Trial
Detection of intracranial venous reflux in patients of transient global amnesia.
The mechanism of transient global amnesia (TGA) is not clear. Attempting to support the hypothesis that retrograde venous hypertension causing cerebral venous ischemia plays a role in the pathogenesis of TGA, the authors used cranial three-dimensional time-of-flight (TOF) MR angiography (MRA) to detect a possible intracranial retrograde venous flow in TGA patients. ⋯ Retrograde intracranial venous flow caused by left brachiocephalic vein occlusion was found only in patients with transient global amnesia (TGA). This result suggests that TGA patients may have an underlying impairment of cerebral venous outflow that increases their vulnerability to TGA attack.