Neurology
-
Randomized Controlled Trial Multicenter Study
Orexin receptor antagonism for treatment of insomnia: a randomized clinical trial of suvorexant.
To assess the utility of orexin receptor antagonism as a novel approach to treating insomnia. ⋯ This study provides Class I evidence that suvorexant improves sleep efficiency over 4 weeks in nonelderly adult patients with primary insomnia.
-
Risk factors have been described for spontaneous intracerebral hemorrhage (ICH); their relative contribution to lobar vs nonlobar hemorrhage location is less clear. Our purpose here was to investigate risk factors by hemorrhage location. ⋯ APOE ε2 or ε4 genotype was associated specifically with lobar ICH. Hypertension was associated specifically with nonlobar ICH. A protective association was seen between hypercholesterolemia and nonlobar ICH; no such association was identified for lobar ICH.