Neurology
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Randomized Controlled Trial Multicenter Study Comparative Study
Adjunctive pregabalin vs gabapentin for focal seizures: Interpretation of comparative outcomes.
To evaluate the comparative safety and adjunctive efficacy of pregabalin and gabapentin in reducing seizure frequency in patients with partial-onset seizures based on prestudy modeling showing superior efficacy for pregabalin. ⋯ This study provides Class II evidence that for patients with partial seizures enrolled in this study, pregabalin is not superior to gabapentin in reducing seizure frequency. Because of the atypical response rates, the results of this study are poorly generalizable to other epilepsy populations.