Neurology
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Multicenter Study
Neurofilament markers for ALS correlate with extent of upper and lower motor neuron disease.
To determine the diagnostic performance and prognostic value of phosphorylated neurofilament heavy chain (pNfH) and neurofilament light chain (NfL) in CSF as possible biomarkers for amyotrophic lateral sclerosis (ALS) at the diagnostic phase. ⋯ This study provides Class II evidence that elevated concentrations of CSF pNfH and NfL can accurately identify patients with ALS.