Neurology
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Multicenter Study
Neurofilament markers for ALS correlate with extent of upper and lower motor neuron disease.
To determine the diagnostic performance and prognostic value of phosphorylated neurofilament heavy chain (pNfH) and neurofilament light chain (NfL) in CSF as possible biomarkers for amyotrophic lateral sclerosis (ALS) at the diagnostic phase. ⋯ This study provides Class II evidence that elevated concentrations of CSF pNfH and NfL can accurately identify patients with ALS.
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To evaluate whether the axonal protein neurofilament light (NFL) in serum is a sensitive biomarker to detect subtle brain injury or concussion in contact sports athletes. ⋯ The results from these 2 independent cohort studies suggest that serum NFL is a highly sensitive biomarker for concussion.
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Multicenter Study Comparative Study Observational Study
Outcome of intracerebral hemorrhage associated with different oral anticoagulants.
In an international collaborative multicenter pooled analysis, we compared mortality, functional outcome, intracerebral hemorrhage (ICH) volume, and hematoma expansion (HE) between non-vitamin K antagonist oral anticoagulation-related ICH (NOAC-ICH) and vitamin K antagonist-associated ICH (VKA-ICH). ⋯ In our international collaborative multicenter pooled analysis, baseline ICH volume, hematoma expansion, 90-day mortality, and functional outcome were similar following NOAC-ICH and VKA-ICH.