Scandinavian journal of gastroenterology
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Scand. J. Gastroenterol. · Jun 1995
Randomized Controlled Trial Clinical TrialAscending colon response to feeding: evidence for a 5-hydroxytryptamine-3 mechanism.
The role of serotonergic type-3 receptors in proximal human colon is unclear. Our aims were to assess the postprandial volume and emptying of the ascending colon and to explore the role of 5-hydroxytryptamine-3 (5HT3) mechanisms. ⋯ The ascending colon response to a meal in health is characterized by a variable initial change in volume, accommodating ileal chyme in some individuals, and a more consistent reduction in volume from 30 to 105 min postprandially. The latter response is inhibited by ondansetron, suggesting partial control of postprandial colonic motor function by 5HT3 mechanisms.