Scandinavian journal of gastroenterology
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Scand. J. Gastroenterol. · Jul 2006
Conservation of whole body nitric oxide metabolism in human alcoholic liver disease: implications for nitric oxide production.
Patients with advanced liver diseases tend to develop a hyperdynamic circulation which complicates cirrhosis. Impairment of nitric oxide (NO) metabolism has been implicated in the pathogenesis of portal hypertension. The aim of this study was to determine nitric oxide synthase (NOS)-dependent whole body NO production in patients with decompensated liver cirrhosis and portal hypertension. ⋯ Our results contraindicate a greater basal NOS-dependent whole body NO production in patients with decompensated liver disease and portal hypertension.