Scandinavian journal of gastroenterology
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Scand. J. Gastroenterol. · Mar 2007
Persistence of Helicobacter pylori infection in patients with peptic ulcer perforation.
In patients with perforated peptic ulcer (PPU) the convergence between the high eradication rate of Helicobacter pylori infection and low rates of ulcer relapse after treatment has been associated with reinfection by non-virulent strains. The objective of this study was to evaluate the persistence of infection by virulent H. pylori strains and ulcer recurrence in 33 patients with PPU one year after surgery and antimicrobial treatment. ⋯ In PPU patients with a low eradication rate of H. pylori infection after surgical and antimicrobial treatment, the frequent recrudescence of the infection is mostly caused by the persisting virulent strains of the cagA and vacA s1a subtypes. In the 1-year follow-up period the recurrent ulceration can be postponed just by the lowered colonization density of H. pylori after eradicative therapy.
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Scand. J. Gastroenterol. · Mar 2007
Controlled Clinical TrialDifferential effect of opioids in patients with chronic pancreatitis: an experimental pain study.
Animal experiments and clinical observations have indicated a different working profile of oxycodone compared to morphine, and it has previously been shown that oxycodone attenuates visceral pain better than morphine. The objective of this study was to test the effects of oxycodone and morphine on experimental pain in patients with pain caused by chronic pancreatitis. ⋯ Oxycodone was a stronger analgesic than morphine in several pain modalities in the skin, muscle and oesophagus.