Scandinavian journal of gastroenterology
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Scand. J. Gastroenterol. · Jul 1997
Comparative StudyRelationship between portal pressure, esophageal varices, and variceal bleeding on the basis of the stage and cause of cirrhosis.
Hepatic venous pressure gradient, esophageal varices, and variceal bleeding were investigated in 957 patients with cirrhosis. The causes (alcoholic/virus) and stage (Child-Pugh's classification) of cirrhosis were also taken into account. ⋯ This study shows that the hepatic venous pressure gradient is associated with the stage and causes of cirrhosis and the presence of varices. These factors should be taken into account in studies evaluating the hepatic venous pressure gradient in heterogeneous groups of patients.
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Scand. J. Gastroenterol. · Apr 1997
Randomized Controlled Trial Multicenter Study Clinical TrialEffect of omeprazole on the outcome of endoscopically treated bleeding peptic ulcers. Randomized double-blind placebo-controlled multicentre study.
Haemostasis is highly pH-dependent and severely impaired at low pH. However, there is no clear evidence that acid-suppressing drugs have beneficial effects in peptic ulcer haemorrhage. Endoscopic haemostatic treatment provides important reduction in morbidity and may be more efficient when a neutral intragastric pH is maintained. ⋯ We found a beneficial effect of intravenous omeprazole in severe ulcer haemorrhage, with a reduction in the number of operations, in endoscopic treatments, and in the duration and severity of bleeding.
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Scand. J. Gastroenterol. · Sep 1996
Three-dimensional ultrasonography of the gastric antrum in patients with functional dyspepsia.
We have developed and validated a three-dimensional ultrasound system for transabdominal imaging. The aims of this study was to evaluate its applicability in scanning and volume estimation of the gastric antrum in humans. ⋯ Three-dimensional ultrasonography by use of a tilting motor makes non-invasive volume estimation of the gastric antrum possible without making assumptions about its geometry. In the present material no difference was found in antral volumes between patients with functional dyspepsia and controls. It is possible that fasting antral volumes in dyspeptic patients are dependent on H. pylori status.
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Scand. J. Gastroenterol. · Jun 1995
Randomized Controlled Trial Clinical TrialAscending colon response to feeding: evidence for a 5-hydroxytryptamine-3 mechanism.
The role of serotonergic type-3 receptors in proximal human colon is unclear. Our aims were to assess the postprandial volume and emptying of the ascending colon and to explore the role of 5-hydroxytryptamine-3 (5HT3) mechanisms. ⋯ The ascending colon response to a meal in health is characterized by a variable initial change in volume, accommodating ileal chyme in some individuals, and a more consistent reduction in volume from 30 to 105 min postprandially. The latter response is inhibited by ondansetron, suggesting partial control of postprandial colonic motor function by 5HT3 mechanisms.