Obstetrics and gynecology
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Obstetrics and gynecology · Mar 2019
Multicenter Study Comparative StudyOral Gonadotropin-Releasing Hormone Antagonist Relugolix Compared With Leuprorelin Injections for Uterine Leiomyomas: A Randomized Controlled Trial.
To investigate the noninferiority of relugolix compared with leuprorelin acetate in reducing heavy menstrual bleeding associated with uterine leiomyomas. ⋯ Takeda Pharmaceutical Company Limited and an affiliate of NovaQuest Capital Management LLC.
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Obstetrics and gynecology · Mar 2019
Meta Analysis Comparative StudyLetrozole Compared With Clomiphene Citrate for Unexplained Infertility: A Systematic Review and Meta-analysis.
To estimate the clinical effectiveness, as determined by positive pregnancy test, of letrozole compared with clomiphene citrate for ovarian stimulation in patients with unexplained infertility. ⋯ Although limited by heterogeneity, studies of ovarian stimulation in women with unexplained infertility show no difference in clinical outcomes between letrozole and clomiphene citrate.
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Obstetrics and gynecology · Mar 2019
Randomized Controlled Trial Comparative StudyPessary Compared With Vaginal Progesterone for the Prevention of Preterm Birth in Women With Twin Pregnancies and Cervical Length Less Than 38 mm: A Randomized Controlled Trial.
To compare the effectiveness of cervical pessary to vaginal progesterone for the prevention of preterm birth in women with twin pregnancies and short cervix. ⋯ ClinicalTrials.gov, NCT02623881.
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Obstetrics and gynecology · Mar 2019
Meta Analysis17α-Hydroxyprogesterone Caproate and the Risk of Glucose Intolerance in Pregnancy: A Systematic Review and Meta-analysis.
To evaluate whether 17α-hydroxyprogesterone caproate use in preventing preterm birth increases the risk of gestational diabetes mellitus (GDM). ⋯ PROSPERO, CRD42016041694.