Masui. The Japanese journal of anesthesiology
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In cesarean section, residual neuromuscular blockade is often observed at the end of the operation. Sugammadex (SGX) is a selective relaxant-binding agent which reverses the blockade at any depth in 2-3 minutes. We investigated whether SGX improves the efficient management of operating rooms. ⋯ SGX decreased the time to extubation after cesarean section under general anesthesia after surgery, and could improve the efficient management of operating rooms.
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Anesthesia is a state made by multiple pharmacological agents that affect the functions of central, peripheral and autonomic nervous systems. Antagonists are often used to reverse the effects of anesthetic agents, muscle relaxants, and so forth. Antagonists often have side effects other than their specific antagonistic effect. ⋯ These agents may antagonize the effects of non-depolarizing muscle relaxants. Flumazenil may have adverse effects in patients on chronic benzodiazepines and tricyclic or tetracyclic antidepressants. Because sugammadex has little adverse effects, it has become a popular agent to reverse muscle relaxation by rocuronium in Japan.
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Many kinds of video-typed laryngoscopes are widely used for tracheal intubation in many clinical situations. The present study was performed to compare the ease in the use of the Airway Scope (AWS), Trueview EVO2 (TVE), and Fibertech Video Laryngoscope (FVL). ⋯ This study suggests that inexperienced medical students would perform tracheal intubation using AWS in a short time without dental click in a simulated manikin.
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Sugammadex was synthesized as a selective reversal agent for rocuronium, a steroidal non-depolarizing neuromuscular blocking (NMB) agent. Sugammadex exerts its effect by forming very tight water-soluble complexes at a 1 : 1 ratio with steroidal NMB agents. Because the reversal of NMB could not sufficiently be completed by anti-cholinesterase agents such as neostigmine, we often had to wait until their spontaneous recovery. ⋯ There is no interaction with cholinergic systems. Therefore, undesired side effects attendant with anti-cholinesterases are not seen. This article provides information on the characteristics and effectiveness of sugammadex.