Acta anaesthesiologica Belgica
-
Acta Anaesthesiol Belg · Jan 1997
Randomized Controlled Trial Multicenter Study Clinical TrialSingle i.v. bolus dose of ondansetron in the prevention of postoperative nausea and emesis.
In this placebo controlled, double blind multicentre study, the efficacy and safety of a single i.v. bolus dose of ondansetron 4 mg were evaluated in the prevention of postoperative nausea and vomiting (PONV), which remains one of the most unpleasant side effects experienced by patients postoperatively. The study population included patients having general anesthesia and undergoing major gynecological or elective abdominal surgery by laparoscopy. ⋯ Several factors appeared to be associated with an increased risk of developing PONV, namely gender (female), type of surgery (gynecological), experience of previous PONV and duration of anesthesia; the use of propofol was not a significant factor. Ondansetron was well tolerated, with no side effect being reported as a significant problem.
-
Acta Anaesthesiol Belg · Jan 1997
Randomized Controlled Trial Comparative Study Clinical TrialIntravenous regional anesthesia. Evaluation of 4 different additives to prilocaine.
Intravenous regional anesthesia (IVRA) is an effective method of producing anesthesia of the extremities. Disadvantages are the rapid loss of anesthesia after the deflation of the tourniquet and the rapid development of postoperative pain. This study compared the effect of four different additives to prilocaine with saline on the development of a complete sensory block, on the return of sensory function after deflation of the tourniquet and on the development of postoperative pain after IVRA for minor orthopedic surgery of the arm. ⋯ The development of a complete sensory block proved significantly faster in the patients receiving sufentanil (4.8 min.) as compared to plain prilocaine (7.5 min.). The return of the sensory function was comparable for all groups. Postoperative pain scores were significantly better in the clonidine and tenoxicam groups.
-
Acta Anaesthesiol Belg · Jan 1997
Randomized Controlled Trial Clinical TrialTenoxicam does not enhance the spread of sensory block produced by intrathecal lidocaine.
Systemic opioids enhance the spread of spinal analgesia. This study was designed to determine whether i.v. tenoxicam, a nonsteroidal anti-inflammatory drug (NSAID), affects the spread of sensory block produced by lidocaine. Sixty patients undergoing transurethral procedures were randomly assigned in a double blind design to receive i.v. either 3 ml normal saline (N/S group, n = 20), or 150 micrograms fentanyl (F group, n = 20), or 40 mg tenoxicam (T group, n = 20), 20 minutes after spinal anesthesia. ⋯ The overall change in the level of sensory block 15 minutes after i.v. treatment was -4.6 +/- 6.3 cm in the N/S group, 2.4 +/- 6.0 cm in the F group, and -1.6 +/- 5.8 cm in the T group. The F group differed from the N/S group (P < 0.01). Intravenous administration of tenoxicam does not enhance the level of spinal analgesia produced by lidocaine.
-
Acta Anaesthesiol Belg · Jan 1997
Randomized Controlled Trial Comparative Study Clinical TrialSevoflurane mask induction in adults: comparison of two inhalation techniques.
The efficacy and safety of two inhalation techniques for mask induction using high concentrations of sevoflurane (8%) were compared in female patients planned for short gynecological procedures in an out-patient setting. One group (n = 20) received single breath vital capacity rapid inhalation induction (VCRII), the other group (n = 20) multiple deep breaths inhalation induction (DBI). ⋯ The respiratory and hemodynamic side effects were also similar. The appreciation of the induction technique was comparable in both groups and most patients agreed to the same inhalation technique with a mask in future anesthetics.