Acta anaesthesiologica Belgica
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Acta Anaesthesiol Belg · Jan 1997
Pentylenetetrazol seizure threshold in the rat during recovery phase from propofol and thiopentone induced anesthesia.
Pentylenetetrazol (PTZ) seizure threshold was determined in the rat during recovery from anesthesia induced by intravenous administration of propofol (20 mg/kg) or thiopentone (30 mg/kg). Seizure threshold values determined 10 min after the induction of anesthesia by either agents were significantly higher than those determined in control animals, indicating an anticonvulsant effect. ⋯ At no time during or after recovery from anesthesia induced by either anesthetic agents, did the PTZ conclusive threshold fall below control values. Thus, using the PTZ convulsive threshold, no proconvulsant effects were detected during the early phase of recovery from propofol or thiopentone induced anesthesia.