Middle East journal of anaesthesiology
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Middle East J Anaesthesiol · Jun 1994
Comparative Study Clinical Trial Controlled Clinical TrialTotal intravenous anesthesia. Midazolam-fentanyl vs enflurane-nitrous oxide.
This study was done to compare the hemodynamics, serum catecholamine levels and postoperative analgesia in total intravenous anesthesia with inhalation anesthesia. Thirteen patients for elective upper abdominal surgery, aged from 40 to 75 years, were studied. In the total intravenous anesthesia group (TIVA group, 7 patients), anesthesia was induced with 0.3 mg.kg-1 midazolam and maintained with 0.68 mg.kg-1.hr-1 midazolam for 15 minutes followed by 0.125 mg.kg-1.hr-1. ⋯ The postoperative analgesic duration in the TIVA group was significantly longer than that in the inhalation group. The elimination half-life of midazolam was 1.675 +/- 0.281 hours in the TIVA group. In this study, TIVA failed to suppress the elevation of serum catecholamine levels, but it achieved stable hemodynamics during upper abdominal surgery and enough postoperative analgesia without affecting the extubation time, the respiratory conditions and the elimination half-life of midazolam.