Revista española de anestesiología y reanimación
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Rev Esp Anestesiol Reanim · Jan 1997
Randomized Controlled Trial Comparative Study Clinical Trial[Efficacy of ondansetron in the prevention of nausea and vomiting after laparoscopic cholecystectomy].
To assess the efficacy of 4 mg of intravenous ondansetron versus placebo for the prevention of postoperative nausea and vomiting (PONV) in cholecystectomy, a type of surgery that is highly emetic. A random, double blind, placebo controlled study of 40 women over 18 years of age who were scheduled for non urgent laparoscopic cholecystectomy under general anesthesia. The patients were assigned to two groups to receive ondansetron (n = 23) or placebo (n = 17). ⋯ There were no significant differences between the two groups with respect to biological characteristics or other factors that might influence the presentation or severity of PONV. The percentage of PONV-free patients was significantly higher in the ondansetron group than in the control group (73.91 and 11.76%, respectively; p < 0.001). Intravenous administration of 4 mg ondansetron is significantly superior to placebo for PONV prophylaxis after laparoscopic cholecystectomy.
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Rev Esp Anestesiol Reanim · Jan 1997
Case Reports[MUltiple sclerosis and obstetric epidural analgesia].
A prior diagnosis of multiple sclerosis (MS) has been considered a contraindication for performing epidural blocks due to the possible negative impact of the course of disease. For this reason, women with MS who given birth have rarely benefited from obstetric epidural analgesia. ⋯ Both the birth and the immediate postpartum period transpired without complications and no new signs of disease were reported over the following years. We conclude that obstetric epidural analgesia with bupivacaine administered at a low concentration is safe for women with MS.