Journal of the Medical Association of Thailand = Chotmaihet thangphaet
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Randomized Controlled Trial Comparative Study
Comparison of minimal fresh gas requirements of baby enclosed afferent reservoir and Jackson Rees anesthetic circuit for general anesthesia in spontaneously breathing children.
The authors compared the baby enclosed afferent reservoir (Baby EAR) with the Jackson-Rees (JR) anesthesia circuit for the minimal fresh gas flow (FGF) requirement with no and clinically acceptable rebreathing in spontaneous breathing anesthesia among pediatric patients. ⋯ Baby EAR can be used safely, effectively, and requires less FGF than JR in pediatric anesthesia in patients weighing 5 to 20 kg.
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Randomized Controlled Trial
Effects of vitamin E on chronic hepatitis C genotype 3: a randomized, double-blind, placebo-controlled study.
Hepatitis C virus (HCV) infection is associated with chronic inflammation and oxidative damage, with hepatic steatosis being common in genotype 3 cases. Vitamin E, a potent antioxidant protective against oxidative stress-induced liver damage in vitro and in vivo, has beneficial effects on alanine aminotransferase (ALT) and histological outcomes in patients with non-alcoholic steatohepatitis. ⋯ Vitamin E treatment decreased serum ALT levels in patients with HCV genotype 3. Because of its good safety profile, vitamin E may be a worthwhile supportive therapy for patients with HCV particularly for those who were unable to achieve viral eradication by standard therapy.
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To compare pregnancy outcomes between women who gave birth at Lerdsin Hospital having gestational weight gain (GWG) within and above or below Institute of Medicine (IOM) guidelines. ⋯ The IOM guidelines are usefulfor monitoring gestational weight gain and if it were within guidelines, women could have decreased riskfor several adverse outcomes such as cesarean birth, macrosomia, LGA, preterm birth, LBW and SGA.
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To document the natural history of brachial plexus birth palsy in relation to the recovery of elbow flexion and shoulder flexion in the first six months of life; to assess the outcome after microsurgery of the brachial plexus in patients who had no recovery of bicep function at six months. ⋯ Most babies with traction injuries of the brachial plexus at birth have an excellent prognosis if the recovery has started within three months. Microsurgical reconstruction was effective in improving function in the small subgroup of patients with no evidence of recovery of bicep function within the first six months of life.
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Clinical Trial
Predictors for low disease activity and remission in rheumatoid arthritis patients treated with biological DMARDs.
Optimal outcome of treatment in rheumatoid arthritis (RA) is early clinical remission to delay joint damage. Therefore, severe RA patients with inadequate response to conventional disease modifying anti-rheumatic drugs (cDMARDs) need highpotency drug as biological DM4RDs (bDMARDs). In general, one-third of RA patient could not get into disease remission with cDMARDs, and half ofthem are still suffering from severe arthritis. However, high cost of this agent is the major barrier for patient engagement, and it is affordable to only 5-10% of patients. We need a good strategy to distribute bDMARDs to patients, especially in limited resource situation. ⋯ Chance to control rheumatoid arthritis in the level of remission or low disease activity is predicted by time of bDAMRDs exposure. This result is mainly influenced by dose ofmethotrexate and number of cDMARDs.