Journal of the Indian Medical Association
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Randomized Controlled Trial Multicenter Study Comparative Study
An open prospective study on postmarketing evaluation of the efficacy and tolerability of diacerein in osteo-arthritis of the knee (DOK).
According to World Health Organisation osteo-arthritis is the second commonest musculoskeletal problem in the world. Diacerein has been recently introduced in India for the treatment of osteo-arthritis. In view of the ulcerogenic potential of NSAIDs and the cardiotoxicity problems associated with COX-2 inhibitors, diacerein has the potential of being a non-ulcerogenic and non-cardiotoxic alternative respectively to NSAIDs and of COX-2 inhibitors in the treatment of osteo-arthritis. ⋯ The severity of the adverse events was mild in all the cases and disappeared with continued treatment. None of the patients dropped out of the study on account of adverse events or lack of efficacy. Thus, in conclusion, the results of the present study in a large population of Indian patients indicates that diacerein constitutes a novel approach to the treatment for the short- and long-term symptomatic management in Indian patients with osteo-arthritis of the knee.
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Case Reports
Pseudo-aneurysm of left ventricle presenting as non-resolving chronic pericardial effusion.
Left ventricular pseudo-aneurysm is a variation of left ventricular free wall rupture, in which collection of blood occurs in pericardial sac, through ventricular wall defect. In pseudo-aneurysm, blood from defect does not fill the entire pericardial sac. Instead, because of adhesions between ventricular wall and the sac, escaping blood is isolated to a localised area between wall and pericardium. Here a case of ventricular pseudo-aneurysm of late onset which behaved as non-resolving pericardial effusion is presented.
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Although exceedingly rare, fulminant hepatic failure in immunocompetent patients can develop with primary or recurrent infection due to herpes simplex virus. The diagnosis is frequently obscured by the absence of mucocutaneous involvement. Elevated transaminases with leucopenia and a relatively low bilirubin level may provide clues to the diagnosis. ⋯ Investigations revealed markedly raised transaminases and coagulopathy. Herpes simplex virus IGM (by ELISA) was positive. The immunocompetent woman was treated with acyclovir but the result was fatal.
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Government of India and Stop TB Partnership strongly feel that Public Private Mix is reaquired to achieve the desired results of eliminating TB as a public health problem by 2050. IMA has accepted and adopted the DOTS strategy of RNTCP. Project Implementation Plan of IMA and GFATM is narrated for the readers to understand IMA GFATM RNTCP PPM. ⋯ In this project IMA has choosen to carry out intensified activities in five states and one union territory in India. With the idea, expected outcomes can be categorised at 3 levels--national, state and district. The individuals of IMA leadership will provide services on an honorary basis, so that the project can be best implemented in its truest sense.