The American review of respiratory disease
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Am. Rev. Respir. Dis. · Jun 1982
Case ReportsFailure of trimethoprim-sulfamethoxazole in the therapy of recurrent Pneumocystis carinii pneumonia.
The use of trimethoprim-sulfamethoxazole in the treatment and prophylaxis of Pneumocystis cariniii is well established. Treatment failure with this regimen has been ascribed to inadequate antibiotic serum concentrations. ⋯ Subsequently, a response to pentamidine isethionate was obtained. The reason for failure and therapeutic implications in patients with Pneumocystis carini pneumonia who have received trimethoprim-sulfamethoxazole are discussed.