Danish medical journal
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Danish medical journal · Jan 2013
ReviewLimited evidence for intranasal fentanyl in the emergency department and the prehospital setting--a systematic review.
The intranasal (IN) mode of application may be a valuable asset in non-invasive pain management. Fentanyl demonstrates pharmacokinetic and pharmacodynamic properties that are desirable in the management of acute pain, and IN fentanyl may be of value in the prehospital setting. The aim of this systematic review was to evaluate the current evidence for the use of IN fentanyl in the emergency department (ED) and prehospital setting. ⋯ Only limited quality evidence exists for the efficacy of IN fentanyl in the ED and in the prehospital setting, and more double-blinded, randomised, controlled trials are urgently needed to validate the use of IN fentanyl in this context.