Danish medical journal
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Danish medical journal · Dec 2014
ReviewCoagulation changes following traumatic brain injury and shock.
In these studies, we have shown that coagulation and innate immunity pathways respond to trauma within minutes. Furthermore, the appearance of dysfunction of platelets as well as activation of the endothelium is rapidly manifested. ⋯ These results add to the growing body of evidence indicating a protective effect of VPA following trauma, and suggests that this may in part be mediated through an attenuation of the above-mentioned pathways. Furthermore, these results indicate that VPA treatment may be effective in other pathological settings such as coagulopathy following trauma or sepsis.
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Danish medical journal · Dec 2014
Pain reduction after percutaneous vertebroplasty for myeloma-associated vertebral fractures.
Percutaneous vertebroplasty (PVP) is a minimally invasive procedure with cement augmentation of vertebral fractures. It was introduced in 1987 as a treatment for painful haemangiomas and is today mostly used for painful osteoporotic fractures of the spine. Two randomised, double-blinded trials published in 2009 have raised a debate about the efficiency of the PVP treatment. The aim of this study was to assess the safety and efficacy of PVP for vertebral body fractures in myeloma patients. ⋯ not relevant.