Danish medical journal
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Danish medical journal · Aug 2015
Randomized Controlled TrialNeuromuscular blockade during laparoscopic ventral herniotomy: protocol for a randomised controlled trial.
Laparoscopic herniotomy is the preferred technique for some ventral hernias. Several factors may influence the surgical conditions, one being the depth of neuromuscular blockade (NMB) applied. We hypothesised that deep neuromuscular blockade defined as a post-tetanic count below eight would provide a better surgical workspace. ⋯ The study is funded by a research grant from the Investigator Initiated Studies Program of Merck Sharp & Dohme Corp.
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The sepsis syndrome represents a disease continuum, including severe sepsis and septic shock associated with high mortality. One of the main problems in severe sepsis and septic shock, resulting in organ failure and death, are disturbances in the hemostasis due to sepsis-related coagulopathy. Sepsis-related coagulopathy affects not only traditional coagulation factors, but also the platelets and endothelium. ⋯ Thus, restoring the broken endothelium and reducing coagulopathy appears to be essential in order to significantly improve sepsis out-comes. MIH could be a promising intervention in sepsis, in part due to the improvement of the coagulopathy. Despite the increased focus on the hemostatic system during sepsis, it seems that continued research on restoring disrupted hemostasis - including endothelial damage - is needed.
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Danish medical journal · Aug 2015
Investigations of functional and structural changes in migraine with aura by magnetic resonance imaging.
Migraine sufferers with aura often report visual discomfort outside of attacks and many consider bright or flickering light an attack-precipitating factor. The nature of this visual hypersensitivity and its relation to the underlying pathophysiology of the migraine aura is unknown. A useful technology to study these features of migraine with aura (MA) is functional magnetic resonance imaging (fMRI), which has the potential not only to detect, but also to localize hypersensitive cortex. The main objective of this thesis was to investigate the cortical responsivity of patients with MA during visual stimulation using fMRI. ⋯ These findings suggest a hyperexcitability of the visual system in the interictal phase of migraine with visual aura. Further, this abnormal function is not dependent on lateralized abnormalities of gray matter structure. However, alteration of the inferior frontal cortex related to headache lateralization could indicate structural reorganization of pain inhibitory circuits in response to the repeated intense nociceptive input due to the headache attacks.