Danish medical journal
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Danish medical journal · Jul 2016
Immunoglobulin for necrotising soft tissue infections (INSTINCT): protocol for a randomised trial.
Necrotising soft tissue infections (NSTI) are aggressive infections that can result in severe disability or death. Intravenous polyspecific immunoglobulin G (IVIG) is used as supplementary treatment for patients with NSTIs. The level of evidence is very low, but suggests that IVIG may have beneficial effects. However, IVIG may also have adverse effects. With this trial we will estimate the effects of IVIG on a patient-reported outcome and other patient-centred outcomes in patients with NSTI. ⋯ The trial is supported by CSL Behring in the form of trial medication and a € 92,182 grant for trial conduct, research, nurse salary and statistical analyses.
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Ventral hernia repairs are among the most frequently performed surgical procedures. The variations of repair techniques are multiple and outcome has been unacceptable. Despite the high volume, it has been difficult to obtain sufficient data to provide evidence for best practice. ⋯ Based predominantly on nationwide data, the present thesis has accomplished pioneering results on outcome from ventral hernia repairs. The results have inspired to increased research and the development of other ventral hernia databases, as well as pointed out a number of risk factors for poor outcome and future challenges in ventral hernia surgery. DVHD and similar registers have a huge potential and can serve as an essential and important platform for further improvement of ventral hernia surgery in the future.