Anesteziologiia i reanimatologiia
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Anesteziol Reanimatol · Nov 2005
Controlled Clinical Trial[Effects of clonidine on the cardiovascular and respiratory systems after cardiac surgery].
The aim of the study was to evaluate the effects of clonidine on the cardiovascular and respiratory systems after cardiac surgery. Ninety-six patients who had undergone scheduled myocardial revascularization were examined. According to the type of used anesthesia, the examinees were divided into 2 groups: 1) 60 patients who received standard anesthesia (a control group) and 2) 36 patients in whom the anesthesia was supplemented by clonidine. ⋯ Statistically significant minimum doses of catecholamines were more frequently used in Group 2 (27% versus 15% in the control group) (p < 0.05). The duration of artificial ventilation was 9.6 +/- 7.5 and 9.2 +/- 5.5 hours in Groups 1 and 2, respectively (p > 0.05). Positive fluid balance within the first 24 postoperative hours was 2324 +/- 1450 and 1587 +/- 1019 ml in Groups 1 and 2, respectively (p > 0.001).
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Anesteziol Reanimatol · Nov 2005
Clinical Trial[Surfactant-BL and inhaled nitric oxide in acute respiratory distress syndrome in cardiac surgical patients].
The study was undertaken to evaluate lung function, central hemodynamics, and the oxygen transport system during combined therapy with surfactant-BL ("Biodurf", Saint Petersburg) and inhalational nitric oxide (iNO) for the acute respiratory distress syndrome (ARDS) after surgery using extracorporeal circulation (EC). Twenty-three patients (18 males and 5 females) aged 43 to 71 years (mean 56.5 +/- 2.4 years) were examined. The diagnosis of ARDS was established in accordance with the criteria recommended by the USA-European Consensus Conference on ARDS. ⋯ Total mortality was 39%. Arterial hypoxemia was not a cause of death in any cases. It is concluded that the combined use of surfactant-BL and iNO ensures significantly improved pulmonary oxygenizing function, decreased thoracopulmonary compliance, and better O2 transport.