The Lancet. Respiratory medicine
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Review Meta Analysis
Long-term survival of critically ill patients treated with prolonged mechanical ventilation: a systematic review and meta-analysis.
Prolonged dependence on mechanical ventilation after critical illness is an emerging public health challenge; however, long-term outcomes are incompletely understood. We aimed to systematically analyse long-term survival of critically ill patients treated with prolonged mechanical ventilation. ⋯ Cooper University Health Care and Cooper Medical School of Rowan University.
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Randomized Controlled Trial Multicenter Study
Efficacy and safety of ivacaftor in patients with cystic fibrosis who have an Arg117His-CFTR mutation: a double-blind, randomised controlled trial.
Ivacaftor has been previously assessed in patients with cystic fibrosis with Gly551Asp-CFTR or other gating mutations. We assessed ivacaftor in patients with Arg117His-CFTR, a residual function mutation. ⋯ Vertex Pharmaceuticals Incorporated.
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Review Case Reports
Acute respiratory distress syndrome after convalescent plasma use: treatment of a patient with Ebola virus disease contracted in Madrid, Spain.
In the current epidemic of Ebola virus disease, health-care workers have been transferred to Europe and the USA for optimised supportive care and experimental treatments. We describe the clinical course of the first case of Ebola virus disease contracted outside of Africa, in Madrid, Spain. ⋯ La Paz-Carlos III University Hospital.
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Randomized Controlled Trial Multicenter Study
Permissive hypercapnia in extremely low birthweight infants (PHELBI): a randomised controlled multicentre trial.
Tolerating higher partial pressure of carbon dioxide (pCO2) in mechanically ventilated, extremely low birthweight infants might reduce ventilator-induced lung injury and bronchopulmonary dysplasia. We aimed to test the hypothesis that higher target ranges for pCO2 decrease the rate of bronchopulmonary dysplasia or death. ⋯ Deutsche Forschungsgemeinschaft.