Journal of anaesthesiology, clinical pharmacology
-
J Anaesthesiol Clin Pharmacol · Apr 2015
Role of flupirtine as a preemptive analgesic in patients undergoing laparoscopic cholecystectomy.
Postsurgical pain is the leading complaint after laparoscopic cholecystectomy that may delay the postoperative recovery and hence we undertook a prospective randomized trial to analyze the role of flupirtine as a preemptive analgesic for postoperative pain relief in patients undergoing above surgery. ⋯ Flupirtine is effective as a preemptive analgesic in providing adequate pain relief during the immediate postoperative period after laparoscopic cholecystectomy surgery. However, continuation of drug therapy postoperatively could possibly delineate its optimal analgesic profile more profoundly.
-
J Anaesthesiol Clin Pharmacol · Apr 2015
Comparison between dexmedetomidine and fentanyl on intubation conditions during awake fiberoptic bronchoscopy: A randomized double-blind prospective study.
Various drugs are used for providing favorable intubation conditions during awake fiberoptic intubation (AFOI). However, most of them cause respiratory depression and airway obstruction leading to hypoxemia. The aim of this study was to compare intubation conditions, and incidence of desaturation between dexmedetomidine and fentanyl group during AFOI. ⋯ Dexmedetomidine is more effective than fentanyl in producing better intubation conditions, sedation along with hemodynamic stability and less desaturation during AFOI.
-
J Anaesthesiol Clin Pharmacol · Apr 2015
A comparison of continuous infusion and intermittent bolus administration of 0.1% ropivacaine with 0.0002% fentanyl for epidural labor analgesia.
Minimal consumption of local anesthetic and opioid for epidural labor analgesia has been advocated for safe obstetric outcome and superior maternal satisfaction. The primary objective of this study was to evaluate and compare the analgesic efficacy of mode of administration of epidural 0.1% ropivacaine with 0.0002% fentanyl via continuous infusion or intermittent boluses during labor. ⋯ Intermittent bolus administration provides a more efficacious route of drug delivery when compared to continuous infusion by significantly decreasing the total amount of local anesthetic plus opioid without adversely affecting patient safety or maternal satisfaction.
-
J Anaesthesiol Clin Pharmacol · Apr 2015
A comparison of the Mallampati test in supine and upright positions with and without phonation in predicting difficult laryngoscopy and intubation: A prospective study.
Difficult ventilation and intubation have been recognized as the forerunners of hypoxic brain damage during anesthesia. To overcome catastrophic events during anesthesia, an assessment of the airway before induction is of paramount importance. We designed this study to compare the effect of phonation on the Mallampati test in supine and upright positions as against the traditionally employed test without phonation in serving to predict difficult laryngoscopy and intubation. ⋯ Based on our results, the supine position along with phonation had the best correlation in the prediction of difficult laryngoscopy and intubation. We further conclude that phonation significantly improved the Mallampati class in the supine position compared with the upright position.
-
J Anaesthesiol Clin Pharmacol · Apr 2015
Comparative study of systemically and perineurally administered tramadol as an adjunct for supraclavicular brachial plexus block.
The study was designed to compare the effects of tramadol administered as an adjunct to bupivacaine in supraclavicular block to that of systemic administration, on postoperative analgesia and rescue analgesic requirement following upper limb surgeries. ⋯ In conclusion, the addition of tramadol to bupivacaine mixtures as an adjunct for supraclavicular brachial plexus block provide better postoperative analgesia for orthopedic upper extremity surgery in comparison to control or systemic tramadol group without any side effects.