World journal of gastroenterology : WJG
-
World J. Gastroenterol. · Feb 2010
ReviewCurrent indications and role of surgery in the management of sigmoid diverticulitis.
Sigmoid diverticulitis is a common disease which carries both a significant morbidity and a societal economic burden. This review article analyzes the current data regarding management of sigmoid diverticulitis in its variable clinical presentations. Wide-spectrum antibiotics are the standard of care for uncomplicated diverticulitis. ⋯ There is not sufficient evidence supporting any changes in the approach to management in younger patients. Conversely, the available evidence suggests that surgery should be indicated after one attack of uncomplicated disease in immunocompromised individuals. Uncommon clinical presentations of sigmoid diverticulitis and their possible association with inflammatory bowel disease are also discussed.
-
World J. Gastroenterol. · Feb 2010
Betaine inhibits toll-like receptor 4 expression in rats with ethanol-induced liver injury.
To test whether ethanol feeding could induce Toll-like receptor 4 (TLR4) responses, assess the hepatoprotective effect of betaine and its inhibitive effect on TLR4 in animal models of alcoholic liver injury. ⋯ Betaine can prevent the alcohol-induced liver injury effectively and improve the liver function. The expression of TLR4 increases significantly in ethanol-fed rats and betaine administration can inhibit TLR4 expression.
-
World J. Gastroenterol. · Feb 2010
Methylation of Dickkopf-3 as a prognostic factor in cirrhosis-related hepatocellular carcinoma.
To investigate the prevalence and time of Dickkopf (DKK) family methylation and its clinical significance in hepatocarcinogenesis. ⋯ Methylation of DKK3 is an important event in early malignant transformation and HCC progression, and therefore might be a prognostic indicator for risk assessment of HCC.
-
World J. Gastroenterol. · Feb 2010
Endoscopic ultrasound-guided celiac plexus neurolysis using a reverse phase polymer.
To assess the feasibility of endoscopic ultrasound (EUS)-guided celiac plexus neurolysis (CPN) using a poloxamer. ⋯ EUS-guided CPN using a reverse phase polymer in a non-survival porcine model was technically feasible. The presence of a poloxamer gel at the site of the celiac plexus at necropsy indicates a precise delivery of the neurolytic agent.
-
World J. Gastroenterol. · Feb 2010
Pericardiocentesis with cisplatin for malignant pericardial effusion and tamponade.
To evaluate the role and outcome of pericardiocentesis with intrapericardial cisplatin instillation for malignant pericardial effusion resulting from esophageal cancer. ⋯ Pericardiocentesis along with catheter drainage appears to be a safe and effective for pericardial malignant effusion and tamponade, and cisplatin instillation prevents recurrence.