World journal of gastroenterology : WJG
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World J. Gastroenterol. · Oct 2013
Review Meta AnalysisRestrictive vs liberal transfusion for upper gastrointestinal bleeding: a meta-analysis of randomized controlled trials.
To compare the outcome of upper gastrointestinal bleeding (UGIB) between patients receiving restrictive and liberal transfusion. ⋯ Restrictive transfusion should be employed in patients with UGIB.
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World J. Gastroenterol. · Oct 2013
Review Meta AnalysisEffects of probiotics on nonalcoholic fatty liver disease: a meta-analysis.
To investigate the relationship between the gut-liver axis and nonalcoholic fatty liver disease (NAFLD), we performed a meta-analysis to evaluate the effects of probiotic therapy in NAFLD. ⋯ Probiotic therapies can reduce liver aminotransferases, total-cholesterol, TNF-α and improve insulin resistance in NAFLD patients. Modulation of the gut microbiota represents a new treatment for NAFLD.
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World J. Gastroenterol. · Oct 2013
Multicenter StudyAntiviral therapy delays esophageal variceal bleeding in hepatitis B virus-related cirrhosis.
To investigate the effect of antiviral therapy with nucleoside analogs in hepatitis B virus (HBV)-related cirrhosis and esophageal varices. ⋯ Antiviral therapy delays the progression of esophageal varices and reduces bleeding risk in HBV-related cirrhosis, however, high-resistance agents tend to be ineffective for long-term treatment.
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World J. Gastroenterol. · Oct 2013
Comparative StudyDifferential diagnosis of left-sided abdominal pain: primary epiploic appendagitis vs colonic diverticulitis.
To investigate the clinical characteristics of left primary epiploic appendagitis and to compare them with those of left colonic diverticulitis. ⋯ If patients have left-sided localized abdominal pain without associated symptoms or laboratory abnormalities, clinicians should suspect the diagnosis of PEA and consider a CT scan.
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World J. Gastroenterol. · Oct 2013
ReviewCurrent position of ALPPS in the surgical landscape of CRLM treatment proposals.
The Authors summarize problems, criticisms but also advantages and indications regarding the recent surgical proposal of associating liver partition and portal vein ligation (PVL) for staged hepatectomy (ALPPS) for the surgical management of colorectal liver metastases. Looking at published data, the technique, when compared with other traditional and well established methods such as PVL/portal vein embolisation (PVE), seems to give real advantages in terms of volumetric gain of future liver remnant. However, major concerns are raised in the literature and some questions remain unanswered, preliminary experiences seem to be promising. ⋯ More data about morbidity and mortality are also expected. The real role of ALPPS is, to date, still to be established. Large clinical studies, even if, for ethical reasons, in well selected cohorts of patients, are expected to better define the indications for this new surgical strategy.