World journal of gastroenterology : WJG
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World J. Gastroenterol. · Aug 2015
Carvedilol may attenuate liver cirrhosis by inhibiting angiogenesis through the VEGF-Src-ERK signaling pathway.
To investigate the effect of carvedilol on angiogenesis and the underlying signaling pathways. ⋯ Carvedilol has an anti-angiogenic effect on HUVECs. This inhibitory effect is mediated by VEGF-induced Src-ERK signaling pathways.
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World J. Gastroenterol. · Aug 2015
Liver transplantation for biliary atresia: A single-center study from mainland China.
To summarize our single-center experience with liver transplantation (LT) for biliary atresia (BA). ⋯ The status of surgical treatments for BA has been changing in mainland China. Favorable midterm outcomes after LT were achieved as centers gained greater technical experience.
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World J. Gastroenterol. · Aug 2015
Comparative StudyFluid resuscitation in acute pancreatitis: Normal saline or lactated Ringer's solution?
To investigate whether administration of Ringer's solution (RL) could have an impact on the outcome of acute pancreatitis (AP). ⋯ Our study failed to find any evidence that the administration of RL in the first days of AP leads to improved clinical outcomes.
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Iron is an important micronutrient that may be depleted in celiac disease. Iron deficiency and anemia may complicate well-established celiac disease, but may also be the presenting clinical feature in the absence of diarrhea or weight loss. If iron deficiency anemia occurs, it should be thoroughly evaluated, even if celiac disease has been defined since other superimposed causes of iron deficiency anemia may be present. ⋯ Rarely, an immune-mediated hemolytic disorder with increased urine iron loss may occur that may respond to a gluten-free diet. Reduced expression of different regulatory proteins critical in iron uptake has also been defined in the presence and absence of anemia. Finally, other rare causes of microcytic anemia may occur in celiac disease, including a sideroblastic form of anemia reported to have responded to a gluten-free diet.
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World J. Gastroenterol. · Aug 2015
Peroral endoscopic myotomy for achalasia in patients aged ≥ 65 years.
To investigate the safety and efficacy of peroral endoscopic myotomy (POEM) for achalasia in patients aged ≥ 65 years. ⋯ POEM is a safe and effective technique for treatment of achalasia in patients aged ≥ 65 years, with improvement in symptoms and quality of life.