Zhonghua wei zhong bing ji jiu yi xue
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Zhonghua Wei Zhong Bing Ji Jiu Yi Xue · Sep 2014
[Study of the mechanisms of curcumin on mitochondrial permeability transition of hepatocytes in rats with sepsis].
To study the effects of mitochondrial permeability transition (MPT) on hepatocyte apoptosis and mitochondrial damage, and investigate the effects of curcumin on MPT and the related mechanisms in septic rat. ⋯ MPT can lead to mitochondrial dysfunction and further cause hepatocyte apoptosis. Mechanism of effect of curcumin on MPT may be related to reduction of intracellular calcium concentration, promotion of anti-apoptotic Bcl-2 gene expression, inhibition of caspase-3 activation and Bax gene.
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Zhonghua Wei Zhong Bing Ji Jiu Yi Xue · Sep 2014
[Effect of time elapsed on continuous pulse contour cardiac output measurement in septic shock patients].
To evaluate the effect of time elapsed on continuous pulse contour cardiac output (PCCO) measurement in septic shock patients. ⋯ Our study in septic shock patients suggests that the accuracy of PCCO will be decreased as the increase of the time interval for calibration. Transpulmonary thermodilution calibration should be performed again if hemodynamic changes or was inconsistent with the clinical presentation. It is suggested that re-calibration should be done within 8 hours.