Zhonghua wei zhong bing ji jiu yi xue
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Zhonghua Wei Zhong Bing Ji Jiu Yi Xue · Feb 2017
Multicenter Study Observational Study[A multicenter confirmatory study about precision and practicability of Sepsis-3].
To clinically validate the precision of diagnostic Sepsis-3 criteria, and to guide and generalize its clinical application. ⋯ Patients satisfied Sepsis-3 were easier to develop more organ failure, Sepsis-3 and higher death prediction than Sepsis-2 and higher diagnosis specificity, but data shows that there is extra room for improvement.
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Zhonghua Wei Zhong Bing Ji Jiu Yi Xue · Feb 2017
Observational Study[Plasma level of neutrophil extracellular traps in septic patients and its clinical significance: a prospective observational study].
To investigate the changes of neutrophil extracellular traps (NETs) level in plasma of sepsis patients and judge its clinical value for early diagnosing of sepsis. ⋯ The plasma cf-DNA/NETs levels increased significantly in sepsis patients. In the diagnosis of sepsis, plasma NETs levels had better advantages over WBC. NETs can be used as a biomarker for early diagnosis of sepsis.
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Zhonghua Wei Zhong Bing Ji Jiu Yi Xue · Feb 2017
Randomized Controlled Trial[Effect of vitamin D3 on the severity and prognosis of patients with sepsis: a prospective randomized double-blind placebo study].
To observe the relationship between vitamin D3 and the severity as well as prognosis in patients with sepsis, and to explore whether exogenous vitamin D3 can improve the prognosis in patients with sepsis. ⋯ The serum 25(OH)D3 level in ICU patients with sepsis was lower than that in healthy people, but there was no significant difference between patients with sepsis and SIRS. The serum 25(OH)D3 level in sepsis patients was related with gender, and the level of the female was lower than that of the male, but was not related with age. Exogenous vitamin D3 supplementation cannot improve the prognosis of ICU patients with sepsis. APACHE II score and 25(OH)D3 < 20 μg/L were risk factors for the prognosis in ICU patients with sepsis.
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Zhonghua Wei Zhong Bing Ji Jiu Yi Xue · Feb 2017
Randomized Controlled Trial[Comparison of effect of norepinephrine and terlipressin on patients with ARDS combined with septic shock: a prospective single-blind randomized controlled trial].
To approach the effect of different vasopressor on hemodynamics, volume responsiveness, fluid volume balance, renal function and prognosis in patients with acute respiratory distress syndrome (ARDS) complicated with septic shock. ⋯ Compared with norepinephrine, terlipressin for ARDS patients with septic shock is more conducive to restrict fluid load, improve the renal perfusion and increase urine output. However, in both groups there was no significant difference in the efficiency of stabilizing hemodynamics, shortening the duration of mechanical ventilation, reducing ICU or hospital days and decreasing 28-day mortality.
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Zhonghua Wei Zhong Bing Ji Jiu Yi Xue · Feb 2017
[Formulation of combined predictive indicators using logistic regression model in predicting sepsis and prognosis].
To explore the method and performance of using multiple indices to diagnose sepsis and to predict the prognosis of severe ill patients. ⋯ The combined predictive indicator, which is formulated by logistic regression models, is superior to any single indicator in predicting sepsis or in-hospital death events.