Zhonghua wei zhong bing ji jiu yi xue
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Zhonghua Wei Zhong Bing Ji Jiu Yi Xue · Jun 2014
Observational Study[Correlation of intestinal fatty acid binding protein and intestinal injury in severe sepsis].
To investigate the content of intestinal fatty acid binding protein (IFABP) and its clinical significance in patients with severe sepsis. ⋯ IFABP concentrations in patients with severe sepsis were significantly increased, and it is correlated well to IL-6, TNF-α and APACHEII score, but did not related obviously with AGI grade and the prognosis of the patients.
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Zhonghua Wei Zhong Bing Ji Jiu Yi Xue · Jun 2014
[An analysis of relevant factors of early death in acute paraquat poisoning].
To determine the clinical indicators of early death (within 72 hours) in patients with acute paraquat poisoning. ⋯ Paraquat concentrations in urine, WBC, Lac, poison dose and PaCO2 were the risk factors of the early death of the acute paraquat poisoning. The research suggests that paraquat concentration in urine, WBC and Lac are valuable in predicting early death of the patients.
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Zhonghua Wei Zhong Bing Ji Jiu Yi Xue · Jun 2014
[Early acute liver injury in paraquat poisoning rats].
To observe hepatocellular apoptosis and inflammatory cytokines expression and their mechanisms after paraquat poisoning in rat. ⋯ Paraquat can cause acute liver injury in rats, with caspase-3, -8, -9, -12 activities markedly enhanced, and liver injury may be associated with an early high expression of TNF-α, iNOS and p53 gene.
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Zhonghua Wei Zhong Bing Ji Jiu Yi Xue · Jun 2014
[Hypoxia/reoxygenation and lipopolysaccharide induced nuclear factor-ΚB and hypoxia-inducible factor-1α signaling pathways in intestinal epithelial cell injury and the interventional effect of emodin].
To observe pathological process of intestinal epithelial cells subjected to ischemia, ischemia/reperfusion injury and inflammation simulated hypoxia/reoxygenation (H/R) and lipopolysaccharide (LPS) challenged human fetal normal colonic cell (FHC) line in vivo, and to observe the changes when the assaulted intestinal epithelial cells were treated with emodin, in order to explore the possible intervention targets of emodin. ⋯ Both hypoxia and inflammation can activate the hypoxia pathway of HIF-1α and the pro-inflammatory pathway of NF-ΚB, but different stimuli cause varying degrees of activation in these two pathways. In H/R group, both pathways were weakened during reoxygenation. However, in H/R + LPS group, the proteins remained to show a relatively high expression during the process of reoxygenation. This may be related to the pathophysiological mechanism of intestinal ischemia/reperfusion injury: hypoxia/reperfusion injury and LPS act together to destroy the intestinal epithelial cells and induce gut-derived sepsis. Emodin may inhibit inflammation by blocking HIF-1α/NF-ΚB-COX-2 signaling pathways.
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Zhonghua Wei Zhong Bing Ji Jiu Yi Xue · Jun 2014
[The role of Nrf2 in the hydrogen treatment for intestinal injury caused by severe sepsis].
To investigate the role of Nrf2 on hydrogen treatment for intestinal injury caused by severe sepsis. ⋯ Through activation of Nrf2-antioxidant response element (ARE) pathway, hydrogen may increase the level of Nrf2, which is a kind of protective protein, in the intestine of mice, thus decreases the level of late pro-inflammatory factor, HMGB1, and it may protect the intestinal tissues in septic mice and increase the survival rate significantly.